IMR Press / EJGO / Volume 19 / Issue 2 / pii/1998141

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Cervical intraepithelial neoplasia and HPV infection

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1 Professor of Obstetrics and Gynecology, Chief of the Department of Obstetrics and Gynecology, Bucharest University Hospital, Romania
2 Biologist, Scientific research, Bucharest University Hospital, Romania
3 Consultant obstetrician and gynecologist, Bucharest University Hospital, Romania
4 Consultant obstetrician and gynecologist, chief of the Maternity Department, Bucharest University Hospital, Romania
Eur. J. Gynaecol. Oncol. 1998, 19(2), 179–181;
Published: 10 April 1998

Human papillomavirus (HPV) infection has been recognized as the major cause of cervical cancer. The transformation zone of the cervix is the most frequent target of the high risk HPV types. In our study infection with HPV 16 and 18 was investigated in the cervical scrapes of 28 subjects with cervical intraepithelial neoplasia. The DNAs isolated from the samples were amplified by dot-blot hybridization with fragmented digoxygenin labelled probes. Eighteen of 28 patients (64.3%) were found positive for HPV16, eleven (39.3%) were found positive for HPV-18 and six patients (21%) were infected with both HPV types. This method is prac­tical and sensitive for determining patients with a higher risk of developing HPV-related cancer.

HPV infection
Dot-blot hybridization
Cervical intraepithelial neoplasia
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