IMR Press / EJGO / Volume 19 / Issue 1 / pii/1998122

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

A close correlation between c-erbB-2 gene amplification and local progression in endometrial adenocarcinoma

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1 Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama, Japan
Eur. J. Gynaecol. Oncol. 1998, 19(1), 90–92;
Published: 10 February 1998
Abstract

The c-erbB-2 proto-oncogene is a gene that encodes a growth factor receptor-like molecule with tyrosine kinase activity. The purpose of this study was to determine whether c-erbB-2 gene amplification measured by the simple and sensitive differential poly­merase chain reaction (PCR) method correlates with clinicopathological factors in endometrial adenocarcinomas. Overall, 7 out of the 38 endometrial adenocarcinomas (18.4%) displayed amplified c-erbB-2 oncogene. No correlation between c-erbB-2 gene ampli­fication and FIGO stage, histologic grade or existence of metastatic disease was found. There was a significant association between c-erbB-2 gene amplification and deep myometrial invasion. In the current study, it has been suggested that c-erbB-2 gene amplifi­cation is possibly involved in local progression but is not closely related to the loss of cell differentiation and metastasis.

Keywords
c-erbB-2
Gene amplification
Endometrial adenocarcinoma
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