IMR Press / EJGO / Volume 19 / Issue 1 / pii/1998111

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

CD44 expression in uterine cervical intraepithelial neoplasia and squamous cell carcinoma: an immunohistochemical study

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1 Department of Pathology, Sheba Medical Center, Tel-Hashomer, affiliated to the Tel-Aviv University, Sackler School of Medicine, Israel
2 Department of the Division of Gynecologic Oncology, Sheba Medical Center, Tel-Hashomer, affiliated to the Tel-Aviv University, Sackler School of Medicine - Israel
Eur. J. Gynaecol. Oncol. 1998, 19(1), 46–49;
Published: 10 February 1998

CD44 is an integral membrane glycoprotein, functioning as the receptor for hyaluronic acid. CD44 is expressed on epithelial, mesenchymal, lymphoid, and glial cells. CD44 distribution, pattern of staining, and isoform types are altered in neoplastic condi­tions, including cervical dysplasia and carcinoma. We have studied CD44 expression by immunohistochemistry in 49 patients with cervical intraepithelial neoplasia (CTN) T, TT, TIT invasive squamous cell carcinoma of the uterine cervix and controls. Only membranous staining was considered positive. Diffuse membranous staining was observed in all controls and CIN I cases, but only in 7/10, 3/10, and 4/9 cases of CIN TT, CTN ITT and squamous cell carcinoma, respectively. The remaining cases showed either complete lack of staining, only focal membra­nous staining or only diffuse inconsistent (weak/cytoplasmic/fragmented) staining. Three invasive carcinomas showed both areas of membranous staining and areas of inconsistent staining in the same section. No correlation was observed between tumor grade and CD44 pattern of staining. Human papillomavirus (HPV) was found in 24/29 high-grade intraepithelial lesions and carcinomas. HPV expression did not correlate with CD44 staining. In conclusion, CD44 expression was found to be reduced in more than 50% of high-grade intraepithelial neoplastic lesions and invasive carcinomas. This might be associated with the loss of cellular adhesion characteristics of pre-invasive and invasive lesions. HPV presence did not seem to influence CD44 expression.

CD44 expression
Cervical neoplasia
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