IMR Press / EJGO / Volume 19 / Issue 1 / pii/1998110

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Estrogen and progestin inhibit invasiveness of gynecologic metastatic cancer cells to blood vessel endothelium

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1 Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan
Eur. J. Gynaecol. Oncol. 1998, 19(1), 42–45;
Published: 10 February 1998

The Boyden chamber method showed that the invasiveness to reconstituted blood vessel endothelium of metastatic gynecologic cancer cell lines of the uterine cervix (MS751 and ME-180), endometrium (AN3 CA), and ovary (SK-OV-3 and PA-1) was signifi­cantly higher than of primary cancer cell lines of the cervix (HeLa and C-33 A), endometrium (Ishikawa, HEC-1-A and HHUA), and ovary (MCAS and Caov-3), and that the invasiveness was inhibited by estradiol or progestin in the metastatic cells but not in the primary cells. These results suggest that metastatic cancer cells by themselves increase the potential of blood vessel invasion, which can be inhibited by estrogen and progestin administration.

Gynecologic metastatic cancer cells
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