IMR Press / EJGO / Volume 18 / Issue 5 / pii/1997155

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Meta-analysis of chemotherapy regimens for ovarian carcinoma: a reassessment of cisplatin, cyclophosphamide and doxorubicin versus cisplatin and cyclophosphamide

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1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Virginia and the Department of Biostatistics, Virginia Commonwealth University, Richmond, USA
Eur. J. Gynaecol. Oncol. 1997, 18(5), 343–348;
Published: 10 October 1997

Objective: To compare three year survival, median survival and improved longevity with the addition of doxorubicin to a che­motherapy regimen of cisplatin and cyclophospamide used in the treatment of ovarian cancer and to integrate this with a previous meta-analysis that compared three year survival. Methods: Twenty-three studies that evaluated either the control or test arms were combined for meta-analysis. Five studies were randomized with both arms. Inclusion criteria consisted of median survival data, three year survival data, no previous chemothe­rapy or radiation and adequate follow-up. The data were analyzed with a twotailed t test, a fixed effects odds ratio, a random effects odds ratio, logistic regression modeling for three year survival and standard regression modeling for median survival. Results: A statistically significant improvement in three year survival was demonstrated with the fixed effects odds ratio analy­sis combining the five prospective randomized studies and with logistic regression model of all the studies. Random effects odds ratio and the two-tailed t test failed to show statistical significance. Standard regression modeling demonstrated statistically significant improvement in median survival for a doxorubicin dose intensity of 40 mg/m2 and near significance for a doxorubicin dose intensity of 50 mg/m2. Median survival was improved by 1.91 months with the addition of doxorubicin to the cisplatin/cyclophosphamide regimen. Conclusion: Although there appears to be statistically significant improvement in three year survival and median survival with the addition of doxorubicin to the cisplatin/cyclophoshamide regimen for ovarian cancer, the actual improvement in median survival is less than two months and therefore, the added toxicity of doxorubicin may not be warranted.

Ovarian cancer
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