IMR Press / EJGO / Volume 18 / Issue 2 / pii/1997123

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Prolonged oral etoposide for advanced uterine leiomyosarcoma with pulmonary metastases

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1 Chulalongkorn University Hospital, Bangkok, Thailand
2 The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
3 Siriraj Hospital, Mahidol University, Bangkok, Thailand
Eur. J. Gynaecol. Oncol. 1997, 18(2), 97–100;
Published: 10 April 1997

A patient who had a high grade uterine leiomyosarcoma with intraabdominal and pulmonary metastases at the time of diagnosis underwent supracervical hysterectomy, bilateral salpingo-oophorectomy and tumor reductive surgery. Induction chemotherapy achieved a partial response with small amount of residual disease. On achieving a plateau in the response to her induction che­motherapy, she was switched to prolonged oral etoposide at a dose of 50 mg /m2/day 21 days with a 7-day rest period between cycles. Follow up imaging revealed stable disease with a slight decrease in the size of the paraaortic lymphnodes. Prolonged oral etoposide may be considered in patients with advanced high grade leiomyosarcoma of the uterus.

Oral etoposide
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