IMR Press / CEOG / Volume 49 / Issue 2 / DOI: 10.31083/j.ceog4902035
Open Access Review
Immunological aspects of ovarian malignancy
Show Less
1 Research Institute of Oncology (IPON)/Department of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, 38025-440 Uberaba-MG, Brazil; (Rosekeila Simões Nomelini)
Academic Editor: Michael H. Dahan
Clin. Exp. Obstet. Gynecol. 2022, 49(2), 35;
Submitted: 22 June 2021 | Revised: 22 July 2021 | Accepted: 9 August 2021 | Published: 8 February 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Objective: Evidence shows that the host’s immune system interacts with tumor development and may be responsible for delaying tumor growth or even for its progression. Chronic inflammation has been identified as a key factor in the pathogenesis of ovarian cancer. The objective of this study is to carry out a comprehensive review of immunological aspects of ovarian cancer. Mechanism: A search of the following keywords was conducted in the PubMed database: “ovarian cancer”, “prognostic factors”, “immunotherapy”, “immune system”. The articles identified were published between 1992 and 2021. Findings in brief: A total of 75 articles were selected for further examination. Conclusions: The understanding of tumor immune escape mechanisms will improve immunotherapy treatments. This will allow personalization or treatment not only in accordance with the biology of the tumor, but also with the characteristics of the tumor microenvironment, expanding the benefit of immunotherapy and providing more effective responses.

Ovarian cancer
Prognostic factors
Immune system
Back to top