IMR Press / CEOG / Volume 48 / Issue 6 / DOI: 10.31083/j.ceog4806215
Open Access Original Research
Comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart disease
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1 Department of Obstetrics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, China
*Correspondence: (Yanping Jiang)
Clin. Exp. Obstet. Gynecol. 2021, 48(6), 1358–1362;
Submitted: 23 February 2021 | Revised: 11 May 2021 | Accepted: 7 June 2021 | Published: 15 December 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Background: The purpose of this study was to explore the clinical value and prognosis of the “prenatal diagnosis-postnatal treatment” model for fetuses with complex congenital heart disease (CHD) by directly comparing the outcomes between prenatal and postnatal diagnosis. Methods: A total of 126 infants with complex CHD diagnosed by prenatal diagnosis and 160 infants with complex CHD diagnosed by postnatal diagnosis in Guangdong Provincial People’s Hospital from January 2012 to December 2017 were enrolled in this retrospective study. The gestational age, birth weight, delivery mode, postpartum termination rate, qualified rate of follow-up assessment of pediatric heart surgery, postoperative complications, postoperative death, time of ventilator weaning, the length of postoperative hospital stay and prognosis were compared between the two groups. Results: There were no significant differences in delivery mode, premature birth rate, gestational age, birth weight, and mean maternal age between the two groups (p > 0.05). However, frequencies of terminating treatment after birth and postoperative complications were significantly higher in postnatal diagnosis group compared with prenatal diagnosis group (p< 0.05), while qualified rate of follow-up assessment of pediatric cardiac surgery was significantly lower in postnatal diagnosis group in comparison with prenatal diagnosis group (p < 0.05). Moreover, postoperative complication rate was significantly higher in the postnatal diagnosis group than prenatal diagnosis group (p < 0.05). Conclusion: Prenatal diagnosis can reduce postoperative complications after cardiac surgery and improve clinical prognosis for fetuses with complex CHD.

Complex congenital heart disease
Prenatal diagnosis
Clinical prognosis
201604020008/Guangzhou Science and Technology plan Major Project of Collaborative Innovation
A2020623/Medical Science and Technology Research Fund Project of Guangdong Province
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