IMR Press / CEOG / Volume 48 / Issue 5 / DOI: 10.31083/j.ceog4805180
Open Access Original Research
Searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinoma
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1 Department of Gynaecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China
*Correspondence: (Ying Gao)
Clin. Exp. Obstet. Gynecol. 2021, 48(5), 1117–1125;
Submitted: 21 March 2021 | Accepted: 13 April 2021 | Published: 15 October 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Background: Polycystic ovary syndrome is a female reproductive system disease closely related to endocrine and highly correlated with the development of endometrial carcinoma in women, it is important to identify the key genes involved in the development of polycystic ovary syndrome. Methods: To identify the hub genes, microarray datasets GSE48301, GSE115810 and GSE3013 were downloaded from Gene Expression Omnibus database. We performed in-depth cross-tabulation bioinformatic analysis to identify differentially expressed genes (DEGs) among four types of endometrial cells in GSE48301 and two endometrial carcinoma datasets GSE115810 and GSE3013, followed by gene ontology, KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment, protein-protein interaction network analysis. Results: Thirteen seed DEGs and 4 significantly expressed DEGs were identified, and potential drugs and mRNAs were found. Conclusion: EDNRA, FBN1, PMP22, SPARC and IGF-1 may be potential and their miRNAs, especially hsa-miR-29a-3p and hsa-miR-29b-3p may be potential biomarkers in the progression from PCOS to endometrial carcinoma.

Differentially expressed genes
Endometrial carcinoma
Insulin-like growth factor 1
Polycystic ovary syndrome
Fig. 1.
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