IMR Press / CEOG / Volume 48 / Issue 4 / DOI: 10.31083/j.ceog4804157
Open Access Case Report
Postpartum hemorrhage and prolonged hyperfibrinolysis as complications of uterine cavernous hemangioma: a case report and literature review
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1 Department of Gynecology, The Fourth Affiliated Hospital of China Medical University, 110004 Shenyang, Liaoning, China
*Correspondence: (Xia Cao)
Clin. Exp. Obstet. Gynecol. 2021, 48(4), 987–990;
Submitted: 13 December 2020 | Revised: 7 January 2021 | Accepted: 14 January 2021 | Published: 15 August 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Background: Uterinecavernous hemangioma can cause persistent vaginal bleeding or massive hemorrhage and can lead to severe pregnancy complications. Case: A 23-year old woman with cutaneous hemangiomas presented for caesarean delivery of her second child nine days after successful delivery, she was admitted with severe postpartum hemorrhage and disseminated intravascular coagulation (DIC). A hysterectomy was performed as a result. The diagnosis of cavernous uterine hemangioma was made only on histopathological examination. In addition, an atypically extended period of refractory fibrinolytic hyperactivity developed after hysterectomy. Such extensive hyperfibrinolysis has not previously been reported in conjunction with hysterectomy. Conclusion: This case underscores the importance of cavernous uterine hemangioma as one of the causes of refractory uterine bleeding at the time of operation delivery. The definitive diagnosis can be made only on histological examination. Changes in the coagulation mechanism should be monitored closely during postpartum, and clinicians should be aware of the possibility of fibrinolytic hyperactivity.

Cavernous hemangioma
Postpartum hemorrhage
Fig. 1.
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