IMR Press / CEOG / Volume 48 / Issue 4 / DOI: 10.31083/j.ceog4804142
Open Access Original Research
The role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio as a supplemental tool for differential diagnosis of uterine myoma and sarcoma
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1 Department of Obstetrics and Gynecology, Catholic University of Daegu School of Medicine, 42472 Daegu, South Korea
*Correspondence: (Youn Seok Choi); (Jung Min Ryu)
These authors contributed equally.
Clin. Exp. Obstet. Gynecol. 2021, 48(4), 901–906;
Submitted: 7 April 2021 | Revised: 1 May 2021 | Accepted: 14 May 2021 | Published: 15 August 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Background: The purpose of this study was to investigate whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can be used as supplemental tools to differentiate between uterine myomas and sarcomas. Methods: From January 2000 to May 2020, patients diagnosed with uterine sarcoma or myoma after surgery at the Catholic University Hospital of Daegu were enrolled in the study. The age and preoperative hematologic findings including hemoglobin, white blood cell count, neutrophils, lymphocytes, platelet counts and lactate dehydrogenase were retrospectively investigated. Results: A total of 366 patients, including 40 uterine sarcoma patients and 326 uterine myoma patients, were included in the study. Among the hematologic findings, NLR and PLR showed statistically significant differences between uterine sarcoma and myoma. The probability of sarcoma was high when NLR was 2.6 and PLR was 150.0. When NLR was 2.6, the odds ratio of uterine sarcoma risk was 9.761 (95% confidence interval [CI]: 3.950–24.120, P < 0.001). When PLR was 150, the odds ratio of uterine sarcoma risk was 3.502 (95% CI: 1.528–8.027, P = 0.003). If NLR was above their cut-offs, the sensitivity of uterine sarcoma diagnosis was 60% and specificity was 83.4%. Identically, PLR was 60% and 73.3%, respectively. Conclusion: NLR and PLR are useful supplemental tools for the differential diagnosis of uterine myoma and sarcoma. Therefore, more expensive and accurate imaging studies, such as magnetic resonance imaging, can be more effectively recommended when these hematologic findings are used together with pelvic ultrasonography.

Uterine neoplasm
Uterine sarcoma
Neutrophil-to-lymphocyte ratio (NLR)
Platelet-to-lymphocyte ratio (PLR)
Fig. 1.
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