IMR Press / CEOG / Volume 48 / Issue 3 / DOI: 10.31083/j.ceog.2021.03.2471
Open Access Original Research
Prescription patterns of herbal medicine for polycystic ovarian syndrome in major Korean medicine hospitals: a multicenter retrospective study
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1 Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 34054 Daejeon, South Korea
2 Clinical Medicine Division, Korea Institute of Oriental Medicine, 34054 Daejeon, South Korea
3 Korean Convergence Medicine, University of Science and Technology, 34113 Daejeon, South Korea
4 Jaseng Hospital of Korean Medicine, 06110 Seoul, South Korea
5 Department of Korean Medicine Gynecology, Kyung Hee University Korean Medicine Hospital at Gangdong, 05278 Seoul, South Korea
6 Department of Gynecology, College of Korean Medicine, Daegu Hanny University, 38610 Gyeongsan, South Korea
7 Department of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Daejeon University, 34520 Daejeon, South Korea
8 Department of Korean Obstetrics & Gynecology, Dongshin University Hospital of Korean Medicine, 58326 Naju, South Korea
*Correspondence:; (Myeong Soo Lee)
Clin. Exp. Obstet. Gynecol. 2021, 48(3), 649–653;
Submitted: 16 January 2021 | Revised: 26 February 2021 | Accepted: 11 March 2021 | Published: 15 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Background: Few studies investigated the prescription patterns of traditional Korean medicine (TKM) therapies for PCOS in clinical practice. The purpose of this study was to identify the common symptoms, herbal prescription patterns and types of adjunctive treatment for treating polycystic ovary syndrome (PCOS) in major traditional Korean medicine (TKM) hospitals. Methods: A retrospective chart review of PCOS patients was used for the study. The study involved the analysis of medical records (ICD-10, polycystic ovary syndrome: E28.2) from four TKM-based university hospitals in South Korea. Results: A total of 120 PCOS patients were analyzed. We found that PCOS patients had a wide range of symptoms, including menstrual irregularity, oligomenorrhea, amenorrhea, acne, infertility, and metrorrhagia. The most commonly prescribed prescriptions for PCOS treatment were Chokyung-san (Tiaojing-san), Gamiguibi-tang (Jiawei Guipi-tang), and Changbudodam-tang (Cangfu Daotan-tang). In addition, patients were most often treated with adjunctive acupuncture and moxibustion. Conclusion: Our study presents the major gynecological herbal prescriptions and other adjunctive therapies used for the treatment of PCOS in TKM-based hospitals. However, further pharmacological investigations and effective clinical trials should be developed to ensure the objectivity of efficacy assessments.

Herbal medicine
Polycystic ovary syndrome
Clinical practice based
Retrospective study
K16292/Korea Institute of Oriental Medicine
KSN2013210/Korea Institute of Oriental Medicine
KSN2021240/Korea Institute of Oriental Medicine
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