IMR Press / CEOG / Volume 48 / Issue 3 / DOI: 10.31083/j.ceog.2021.03.2348
Open Access Original Research
A dilemma for women: having many children risks deterioration of diastolic functions
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1 Department of Cardiology, Eskisehir City Hospital, 26100 Eskisehir, Turkey
2 Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, 32000 Isparta, Turkey
3 Department of Cardiology, Faculty of Medicine, Kutahya Dumlupinar University, 43000 Kutahya, Turkey
*Correspondence: (Mehmet Ozgeyik)
Clin. Exp. Obstet. Gynecol. 2021, 48(3), 550–554;
Submitted: 4 November 2020 | Revised: 10 December 2020 | Accepted: 11 December 2020 | Published: 15 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Background: Echocardiography is the most widely used diagnostic tool for detecting changes in cardiac function. Pregnancy is a dynamic process that affects the cardiovascular system and recent studies have shown that increased parity may cause irreversible changes in the cardiovascular system. In this study, we aimed to evaluate echocardiographic changes in women, especially grand multiparous (6 to 9 parities) and great grand multiparous (more than 9 parities) women, after all their pregnancies had finished. Methods: This was a cross-sectional study and contained 195 female patients. Women with one delivery were defined as primiparous (PP), 2 to 5 deliveries were defined as multiparous (MP), 6 to 9 deliveries were defined as grand multiparous (GMP) and more than 9 deliveries were defined as great grand multiparous (GGMP). Results: The mean age at cardiac evaluation was 50.6 ± 16.3 and mean parity was 6.5 ± 4.2. Diastolic dysfunction was grouped as grade 1–3 and this was determined according to the E/e’ ratio. Spearman correlation analysis showed that diastolic dysfunction had positive correlations with parity, age, hypertension, and diabetes mellitus. Receiver-operating curve (ROC) analysis showed that the best cut-off value of the parity number for predicting left ventricular diastolic dysfunction was 6.5, with 66.3% sensitivity and 66.7% specificity. Discussion: In the present study, we showed that diastolic dysfunction significantly increased as the number of pregnancies increased. Additionally, the cut-off value of parity for diastolic dysfunction was 6.5 which is higher than other studies.

Left ventricular dysfunction
Fig. 1.
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