IMR Press / CEOG / Volume 48 / Issue 3 / DOI: 10.31083/j.ceog.2021.03.2340
Open Access Original Research
The relationship between fetal thymus volume and preterm birth in dichorionic diamniotic pregnancies
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1 Departments of Obstetrics and Gynecology, School of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
*Correspondence: (Emine Seda Guvendag Guven)
Clin. Exp. Obstet. Gynecol. 2021, 48(3), 528–533;
Submitted: 28 October 2020 | Revised: 25 December 2020 | Accepted: 31 December 2020 | Published: 15 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Background: The aim of this study was to compare fetal thymus volume in women who delivered at <36 weeks of pregnancy versus those who did not. Methods: A total of 32 dichorionic-diamniotic twin pregnant women were included in the prospective cohort study. The fetal thymus volumes were measured in the second trimester for each fetus using the VOCAL ultrasonography program. The data of women who experienced preterm labor (delivered at <36 weeks of pregnancy) and the control group (delivered at 36 weeks of pregnancy) were compared. Results: The mean thymus volume of each fetus was statistically significantly lower in preterm delivery cases than in the control group. Mean fetal thymus volume could be used as a marker for predicting preterm birth in the study group. The parameter of fetal thymus volume measured in twins at 18–24 weeks can be used as a predictive factor (P < 0.001). When the fetal thymus volume, measured 3-dimensionally by ultrasonography in conjunction with the VOCAL program, was used as a marker for predicting preterm delivery, the cut-off value was found to be 0.5245 cm3, with 83.3% sensitivity and 85.8% specificity (AUC 0.905, P < 0.001, 95% CI, 0.798–0.930). Conclusion: By predicting preterm delivery via measuring the fetal thymus volume in twins, physicians can suggest strategies to prevent preterm delivery at 18–24 weeks of pregnancy. In this way, fetal mortality/morbidity related to preterm delivery may be prevented.

Dichorionic-diamniotic pregnancy
Fetal thymus volume
Preterm labor
Twin pregnancy
Fig. 1.
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