IMR Press / CEOG / Volume 48 / Issue 2 / DOI: 10.31083/j.ceog.2021.02.2265
Open Access Systematic Review
Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis
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1 Department of Obstetrics, Guangdong Women and Children Hospital, 510510 Guangzhou, Guangdong, China
2 Department of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, 510510 Guangzhou, Guangdong, China
3 Department of Internal Medicine of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Southern Medical University, 510510 Guangzhou, Guangdong, China
*Correspondence: (Jun-Qing Zhu); (Li-Sheng Wu)
Clin. Exp. Obstet. Gynecol. 2021, 48(2), 245–252;
Submitted: 20 August 2020 | Revised: 3 November 2020 | Accepted: 16 November 2020 | Published: 15 April 2021
Copyright: © 2021 The Authors. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Hypertensive disorders of pregnancy (HDP) encompass a group of diseases. Single nucleotide polymorphisms (SNPs) are common in the matrix metalloproteinase 9 (MMP9) genes. The objective of this study was to analyse whether genetic polymorphisms in MMP9-1562 C/T alter the risk of HDP. Studies published up to October 2019 across PubMed, ScienceDirect, SpringerLink, and China National Knowledge Infrastructure database were searched. Case-control or cohort studies involving subtypes of HDP and distribution of genotypes and/or alleles within MMP9-1562 C/T in both patients and controls were selected. Number of genotypes and/or alleles for MMP9-1562 C/T polymorphisms were obtained and analyzed using Stata software. Eight published reports including 1300 HDP patients and 1612 controls were included in the meta-analysis. Results showed that a variant genotype and allele of MMP9-1562 C/T increased the risk of HDP, with pooled OR 1.50 (95% CI 1.16–1.95, P = 0.002) and 1.36 (95% CI 1.15–1.61, P < 0.001). Subgroup analyses showed that the variant genotype and allele of MMP9-1562 C/T also had increased risk of preeclampsia (OR = 1.48, 1.32; 95% CI 1.18–1.86, 1.08–1.62; P = 0.001, 0.007) and gestational hypertension (OR = 2.23, 1.88; 95% CI 1.52–3.28, 1.33–2.65; P < 0.001, < 0.001) in the fixed-effects models. This suggests that variant genotype (TT + TC) and allele (T) of MMP9-1562 C/T are associated with susceptibility of HDP, especially preeclampsia and gestational hypertension.

Hypertensive disorders of pregnancy
Gestational hypertension
Matrix metalloproteinase 9
Single nucleotide polymorphism
81803932/Natural Science Foundation of China
2018030310025/Natural Science Foundation of Guangdong Province
2017A030313868/Natural Science Foundation of Guangdong Province
2017Z020 and 2016C024/President Foundation of Nanfang Hospital, Southern Medical University
Fig. 1.
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