IMR Press / CEOG / Volume 48 / Issue 1 / DOI: 10.31083/j.ceog.2021.01.2131
Open Access Original Research
Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study
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1 Department of Obstetrics and Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of medical sciences, 61357-15794 Ahvaz, Iran
2 Ahvaz Jundishapur University of Medical Sciences; Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, 61357-15794 Ahvaz, Iran
*Correspondence: (Mahvash Zargar)
Clin. Exp. Obstet. Gynecol. 2021, 48(1), 179–184;
Submitted: 7 May 2020 | Revised: 9 November 2020 | Accepted: 13 November 2020 | Published: 15 February 2021
Copyright: © 2021 The Authors. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Purpose: Evaluation of the effect of platelet-rich plasma (PRP) containing platelet-derived growth factor on in vitro fertilization (IVF) failure patients. Methods: In this clinical trial, 80 eligible patients (infertile women with at least two IVF failures) were randomly assigned into two groups, including patients who received an intrauterine infusion of PRP (n: 40) and controls (n: 40). Before PRP therapy, standard hormone replacement therapy was performed for all patients to endometrial thickness preparation. After sonographic assessment of endometrium, PRP was injected into all patients’ endometrium whether they had an appropriate endometrial thickness or not. Then, the embryo transferring was done through IVF. Eventually, the consequences of fertility, embryo implantation, and pregnancy were evaluated. Data analysis was performed using SPSS version 22. Results: The rate of successful IVF [6 (15%)], pregnancy rate [5 (12.5%)], and live birth [5 (12.5%)] were relatively higher in patients undergoing PRP therapy compared with controls [2 (5%), 1 (2.5%) and 0, respectively]. However, their statistical difference was not significant between the two groups (P > 0.05). Conclusion: Our findings suggest that endometrial injection of platelet-rich plasma for IVF failure patients did not significantly improve the IVF process, pregnancy, and live birth rates.

Platelet-rich plasma
Platelet-derived growth factor
In vitro fertilization
Pregnancy rate
Live birth
Ahvaz Jundishapur University of Medical Sciences
Fig. 1.
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