IMR Press / CEOG / Volume 47 / Issue 5 / DOI: 10.31083/j.ceog.2020.05.5360
Open Access Original Research
Gestational age estimation from ultrasound fetal biometrics in China
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1 Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, College of Physics, Chongqing University, Chongqing, P.R. China
2 Department of ultrasound, University-Town Hospital of Chongqing Medical University, Chongqing, P.R. China
3 Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
4 College of Mathematics and Statistics, Chongqing University, Chongqing, P.R. China
5 Health Management Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
6 Department of Obstetrics and Gynecology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
7 Chongqing Pepper Technology Co., Ltd. Chongqing, P.R. China
*Correspondence: (LIYU LIU)
Clin. Exp. Obstet. Gynecol. 2020, 47(5), 714–722;
Submitted: 30 August 2019 | Accepted: 18 March 2020 | Published: 15 October 2020
Copyright: © 2020 Sun et al. Published by IMR press
This is an open access article under the CC BY 4.0 license

Objective: To establish a new gestational age estimation equation in China and compare them with commonly used equations of 2017 and 1984. Methods: A prospective cross-sectional study was performed in 3208 fetuses between 15 and 40 weeks of gestation. The following biometric variables were recorded: biparietal diameter, head circumference, abdominal circumference, and femur length. Women with a certain gestational age were confirmed by the last menstrual period with a regular cycle of 26-32 days. Subsequently, a mixed regression model was used for regression analysis for the estimation equation of gestational age. Additionally, validation set was used to verify the accuracy of the equation. Estimation error was defined as the mean square deviation between the estimation equation and observed gestational age and its accuracy was compared with that analyzed by Hadlock and National Institute of Child Health and Human Development (NICHD) equations. Results: The gestational age estimation errors of the new equation are within 9.62 days from 15 to 20 weeks, 7.90 days from 21 to 25 weeks, 11.76 days from 26 to 30 weeks, 9.35 days from 31 to 35 weeks, and within 11.30 days from 36 to 40 weeks of gestation. Compared to the results evaluated by the Hadlock and NICHD equations, the estimation of the new equation has significantly improved gestational age determination in the second and third trimesters. Conclusions: The estimation results of the new equation is superior to those of the Hadlock and NICHD equations and provides more accurate results for gestational age estimation with ultrasonic examination.

Biparietal diameter
Head circumference
Abdominal circumference
Femur length
11974066/National Natural Science Foundation of China
11674043/National Natural Science Foundation of China
cstc2019jcyj-msxmX0477/Natural Science Foundation of Chongqing
cstc2018jcyjA3679/Natural Science Foundation of Chongqing
2019CDYGYB007/Fundamental Research Funds for the Central Universities
Figure 1.
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