IMR Press / CEOG / Volume 47 / Issue 4 / DOI: 10.31083/j.ceog.2020.04.5144
Open Access Original Research
Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats
Show Less
1 Department of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan
2 Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
3 Department of Functional Anatomy, School of Nursing, University of Shizuoka, Shizuoka, Japan
*Correspondence: (HIROSHI MATSUSHITA)
Clin. Exp. Obstet. Gynecol. 2020, 47(4), 546–551;
Submitted: 1 February 2019 | Accepted: 1 April 2019 | Published: 15 August 2020
Copyright: © 2020 Tachibana et al. Published by IMR Press.
This is an open access article under the CC BY 4.0 license

Purpose: This animal experiment investigated how sesame seed (Sesamum indicum; SSI) extract affects bone metabolism in ovariectomized (Ovx) rats. Materials and methods: Female Wistar rats (12 weeks old) were randomly assigned to the Baseline control (BC), Sham, Ovx, and Ovx + SSI groups (n = 6-10). Animals in the BC group were sacrificed immediately. Rats in the other groups underwent sham surgery (Sham) or bilateral ovariectomy (Ovx and Ovx + SSI). Rats in the Ovx + SSI group were given custom diets, and BMD and bone histomorphometry were evaluated 13 weeks post-surgery. Results: The femur BMD in the Ovx + SSI group was lower than in the Ovx group, as were the measurements for bone formation rate and mineralizing surface. Conclusion: Administration of a methanol extract of sesame seeds decreased femur BMD in Ovx rats.

Bone mineral density
Bone histomorphometry
Japan Society for Menopause and Women's Health to A.M.
Figure 1.
Back to top