IMR Press / CEOG / Volume 47 / Issue 4 / DOI: 10.31083/j.ceog.2020.04.4267
Open Access Case Report
Anti-E alloimmunization in a pregnancy with a low antibody titer
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1 Department of Obstetrics and Gynecology, Nayoro City General Hospital, Nayoro, Japan
2 Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan
3 Department of Pediatrics, Nayoro City General Hospital, Nayoro, Japan
*Correspondence: (TOSHINOBU MIYAMOTO)
Clin. Exp. Obstet. Gynecol. 2020, 47(4), 614–616;
Submitted: 29 March 2017 | Accepted: 31 May 2017 | Published: 15 August 2020
Copyright: © 2020 Nakanishi et al. Published by IMR Press.
This is an open access article under the CC BY 4.0 license

Red blood cell alloimmunization during pregnancy causes hemolytic disease of the fetus and newborn. While alloimmunization in pregnancy is treatable with anti-D antibodies, management with other antibodies has not been studied. A 32-year-old woman had anti-E antibodies detected during pregnancy, but the titer was < 1 : 2. Her newborn was admitted to hospital because direct Coombs tests were positive. Low titers of maternal anti-E antibodies were found in the newborn. We performed phototherapy and administered intravenous immunoglobulin because the newborn showed early jaundice and hyperkalemia, which suggested hemolytic disease. After being discharged at 6 days of age, the baby was readmitted to hospital at 9 days because of recurrent jaundice and underwent phototherapy. The baby was later discharged without recurrence of jaundice. Low anti-E antibody titers in pregnancy can cause alloimmunization, which can be treated successfully. The potential risk of hemolytic disease should be considered in cases with such low titers.

Anti-E antibody
Hemolytic disease of the fetus and newborn
Rho(D) immunoglobulin.
Figure 1.
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