IMR Press / CEOG / Volume 47 / Issue 1 / DOI: 10.31083/j.ceog.2020.01.5100
Open Access Original Research
Elastin genetic point mutation and the risk of pelvic organ prolapse
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1 Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion University, Haifa, Israel
2 Faculty of Natural Sciences, University of Haifa, Israel
*Correspondence:; (I FEFERKORN)
Clin. Exp. Obstet. Gynecol. 2020, 47(1), 75–78;
Published: 15 February 2020
Copyright: © 2020 Haya et al. Published by IMR press.
This is an open access article under the CC BY-NC 4.0 license

Aim: A missense mutation in the elastin gene (g28197A > G) is associated with an increased risk for inguinal hernias. Due to the shared epidemiological and pathophysiological features between pelvic organ prolapse (POP) and inguinal hernias, the authors hypothesized that a similar association exists between elastin gene polymorphism and POP. Materials and Methods: Patients of Ashkenazi Jewish origin with advanced (stage III-IV) POP (as assessed by POP-Q) and healthy controls were compared for the presence of the elastin gene g28197A > G missense mutation. Results: The missense mutation in the elastin gene was not found in neither the study or the control group. Conclusion: The elastin gene g28197A > G missense mutation was not found to be associated with an increased risk for POP.

Genetic polymorphism
Pelvic organ prolapse
Point mutation
Figure 1.
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