IMR Press / CEOG / Volume 47 / Issue 1 / DOI: 10.31083/j.ceog.2020.01.4987
Open Access Original Research
Effect of the methanol extract of the Lion’s Mane mushroom, Hericium erinaceus, on bone metabolism in ovariectomized rats
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1 Department of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute, Japan
2 Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
3 Department of Functional Anatomy, School of Nursing, University of Shizuoka, Shizuoka, Japan
*Correspondence: (H. MATSUSHITA)
Clin. Exp. Obstet. Gynecol. 2020, 47(1), 47–52;
Published: 15 February 2020
Copyright: © 2020 Morita et al. Published by IMR press.
This is an open access article under the CC BY-NC 4.0 license

Purpose: Osteoporosis is a major health concern in postmenopausal women. The aim of the study was to investigate the effect of Hericium erinaceus (H. erinaceus), also known as the Lion’s Mane mushroom, consumption on bone metabolism in ovariectomized (Ovx) rats. Materials and Methods: Rats in the Baseline group were sacrificed immediately, whereas rats in the Sham group underwent sham surgery, and those in the Ovx and Ovx + HE groups underwent bilateral Ovx. A diet containing the methanol extract of H. erinaceus was given to the Ovx+HE group for 13 weeks. Results: There was no significant difference in the femoral bone mass between the Ovx and Ovx+HE groups. In the histomorphometric study of the proximal tibial metaphysis, the osteoblast surface, mineralizing surface, and fat cell number were lower in the Ovx+HE group than those in the Ovx group. Conclusion: The present findings suggest that H. erinaceus does not prevent but rather accelerates bone loss in Ovx rats.

Bone histomorphometry
Bone mineral density
Figure 1.
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