IMR Press / CEOG / Volume 46 / Issue 6 / DOI: 10.12891/ceog4801.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Hereditary thrombophilia in the puerperium: a retrospective review of 11 cases complicated by cerebral venous thrombosis
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1 Department of Obstetrics and Gynecology, Faculty of Medicine, "Gr.T.Popa" University of Medicine and Pharmacy, Iasi, Romania
2 “Cuza Vodă” University Hospital, Iasi, Romania
3 “Saint John” Emergency Hospital, Suceava, Romania
*Correspondence: (PETRONELA VICOVEANU)
Clin. Exp. Obstet. Gynecol. 2019, 46(6), 897–902;
Published: 10 December 2019

Purpose of Investigation: The purpose of this study was to conduct a multidisciplinary analysis of a 11 cases of cerebral venous thrombosis in the puerperium associated with hereditary thrombophilia. Materials and Methods: The medical records of patients with ereditary thrombophilia and cerebral venous thrombosis in the puerperium were reviewed retrospectively. Clinical suspicion of cerebral venous thrombosis had been confirmed by CT or MRI. Results: Only in 11 cases the authors found the association between hereditary thrombophilia and cerebral thrombosis. The evaluation of the thrombophilic profile revealed that MTHFR C677T in combination with Factor V Leiden G1691A and Prothrombin G20210A were the commonest gene defects among cases studied. Conclusion: Hereditary thrombophilia may increase the risk of cerebral venous thrombosis in the puerperium.

Cerebral thrombosis
Figure 1.
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