IMR Press / CEOG / Volume 46 / Issue 5 / DOI: 10.12891/ceog4747.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Is there a relationship between systemic inflammatory markers and abnormal uterine bleeding in unclassifiable cases according to the PALM-COEIN system?
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1 Department of Gynecology and Obstetrics, İzmir Katip Çelebi University Atatürk Research and Training Hospital, İzmir, Turkey
2 Department of Statistics, İzmir, Turkey
3 Department of Gynaecology and Obstetrics, İzmir Katip Çelebi University School of Medicine, İzmir, Turkey
4 Department of Gynaecology and Obstetrics, Private Kordon Surgery Center, İzmir, Turkey
*Correspondence: (H. AYDOĞMUŞ)
Clin. Exp. Obstet. Gynecol. 2019, 46(5), 752–756;
Published: 10 October 2019

Objective: The aim of this study is to assess the possibility of subclinical inflammation and the difference of SIR markers in cases with abnormal uterine bleeding (AUB). Materials and Methods: A total of 529 women were enrolled in the study. Patients were classified according to diagnostic categories of PALM-COEIN. The comparisons between the groups were analyzed by one way variant analysis and Kruskal-Wallis analysis. Relations between numerical variables were assessed by Spearman Correlation analysis. Results: No significant difference was found between the groups for SIR markers. When SIR markers were compared between the groups Neutrophil / lymphocyte ratio (NLR) was negatively correlated with lymphocyte/platelet ratio (LPR) in all the groups. Although a strong negative correlation was detected between NLR and lymphocyte/monocyte ratio (LMR) in Groups 2, 3, and 4, no significant relation was detected in Group 1. Conclusions: In this study, no significant difference of SIR markers was observed between AUB cases with functional or structural abnormalities and unclassifiable AUB cases according to PALM-COEIN classification.

Abnormal uterine bleeding
Systemic inflammatory response markers
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