IMR Press / CEOG / Volume 46 / Issue 5 / DOI: 10.12891/ceog4726.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Pregnancy outcomes in patients with Marfan syndrome
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1 Department of Obstetrics and Gynecology, Medical Center of Severe Cardiovascular of Beijing Anzhen Hospital, Beijing, China
2 Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Beijing, China
*Correspondence: (JUN ZHANG)
Contributed equally to this work.
Clin. Exp. Obstet. Gynecol. 2019, 46(5), 805–811;
Published: 10 October 2019

Objective: The aims of this study were to evaluate the clinical characteristics of pregnant patients with Marfan syndrome and the maternal and fetal outcomes. Materials and Methods: Twelve pregnant women with Marfan syndrome were identified, who were treated in Beijing Anzhen Hospital Affiliated to Capital Medical University between January 2012 and May 2016. Results: Among 12 patients, six cases were diagnosed as type A aortic dissection, four cases were diagnosed as type B aortic dissection, one case had aortic dissection surgery before pregnancy, and one case was diagnosed with expansion of aortic sinus. Among the 12 cases, except for one patient with cardiac tamponade leading to heart failure, the remaining 11 cases had no complications. Six cases of newborns had a birth body mass between 1,080 to 3,500 grams; one case died after 14 days and five cases of newborns were alive without exception. Conclusion: Aortic dissection poses a serious risk for pregnant women with Marfan syndrome and the fetus, and the mortality rates for both the mother and the fetus are high. Early diagnosis and appropriate treatment should be based on maternal and fetal conditions. A multi-disciplinary team between obstetric and cardiovascular surgery is crucial in the outcome of these critical patients.

Marfan syndrome
Pregnancy outcome
Cardiac surgical procedure
Extracorporeal circulation
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