IMR Press / CEOG / Volume 46 / Issue 4 / DOI: 10.12891/ceog4733.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report
The relationship between vaginal cavernous hemangiomas and late pregnancy. A case report and a review of the literature
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1 Department of Pathology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Saitama, Japan
*Correspondence: (JUN-ICHI TAMARU)
Clin. Exp. Obstet. Gynecol. 2019, 46(4), 641–645;
Published: 10 August 2019

The occurrence of cavernous hemangiomas in the vagina is very rare. A 34-year-old woman at 33 weeks’ gestation was admitted with a large reddish mass of approximately 5 cm in diameter in the vagina, with bleeding and a sensation of discomfort with walking. The vaginal mass was excised to confirm the pathological diagnosis. Histopathological analysis showed various dilated vessels lined by increased endothelial cells, and the final diagnosis was vaginal cavernous hemangioma. The immunohistochemical analysis showed positive expressions of vascular endothelial growth factor (VEGF), estrogen receptor (ER), and progesterone receptor (PgR) in perivascular stromal cells around the hemangioma. Additionally, the authors reviewed the relationship between genital hemangiomas and pregnancy from the literature. In the female genital tract, six (75%) of eight vaginal hemangiomas were associated with pregnancy, in particular, late pregnancy, in addition to the present case, and eight (32%) of 25 cervical hemangiomas were seen in late pregnancy. Taken together, the hormonal status in late pregnancy may affect the formation of vaginal hemangiomas.

Hormonal status
Figure 1.
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