IMR Press / CEOG / Volume 46 / Issue 3 / DOI: 10.12891/ceog4859.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Increased Th17 and reduced Treg cells in patients with unexplained recurrent spontaneous abortion
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1 Guizhou Provincial People’s Hospital, Guiyang, China
*Correspondence: (YAN GAO)
Clin. Exp. Obstet. Gynecol. 2019, 46(3), 458–460;
Published: 10 June 2019

Immune imbalance of T cells in the maternal-fetal interface is reported to be associated with unexplained recurrent spontaneous abortion (URSA), such as Th17/Tregs/Th1/Th2 cell. The authors’ previous finding demonstrated that the percentage of Th1 cells was higher in the decidual tissues of patients with URSA. However, whether Th17 and Treg cells are altered in URSA remains unknown. In this study, the authors measured the percentage of Th17 and Treg cells by flow cytometry in 30 URSA patients and 30 normal pregnant women. They found that there were a higher proportion of Th17 and a lower number of Treg cells in the decidual tissue of URSA compared to those in normal controls. In conclusion, the results indicate that the changes in the proportion of Th17 and Treg cells in the maternal-fetal interface may be related to the occurrence of URSA.

Maternal-fetal interface
Th17 cells
Treg cells
Unexplained recurrent spontaneous abortion
Figure 1.
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