IMR Press / CEOG / Volume 46 / Issue 3 / DOI: 10.12891/ceog4703.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Adjusting progesterone (P) dosage to compensate for a non-homogeneous hyperechogenic (HH) echo pattern three days after embryo transfer
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1 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA
2 Cooper Institute For Reproductive Hormonal Disorders, P.C., Mt. Laurel, NJ, USA
*Correspondence: (J.H. CHECK)
Clin. Exp. Obstet. Gynecol. 2019, 46(3), 356–358;
Published: 10 June 2019

Purpose: To determine if in the modern era failing to attain a homogenous hyperechogenic (HH) pattern three days after embryo transfer is still associated with a lower pregnancy rates. The study evaluates the efficacy of adding extra progesterone (P) at the time of the non-HH pattern. Materials and Methods: A five-year retrospective cohort analysis was performed evaluating two age groups (≤ 34 vs. 35-39 years). If an HH pattern was not attained, 50 mg IM P was added to the vaginal P supplementation already given in the IVF-ET cycle. The first two IVF cycles were evaluated. Results: There was no difference in live delivered pregnancy rates in younger women not attaining the HH pattern but it was lower in those aged 36-39 years. Conclusions: A randomized study adding extra IM P or not in women aged 36-39 or even the younger women is needed to determine if adding extra IM P improves the pregnancy rates or not.

Mid-luteal phase
Endometrial echo pattern
In vitro fertilization
Live delivered pregnancy rate
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