IMR Press / CEOG / Volume 46 / Issue 3 / DOI: 10.12891/ceog4607.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Novel inflammatory markers of labor following premature preterm rupture of membranes
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1 Department of Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland
2 Department of Laboratory Diagnostics, Pomeranian Medical University, Szczecin, Poland
*Correspondence: (R. RZEPKA)
Clin. Exp. Obstet. Gynecol. 2019, 46(3), 359–367;
Published: 10 June 2019

The aim of the study was comparison of levels of resistin (RE), soluble receptor for advanced glycation end products (sRAGE), soluble receptor activator for nuclear factor-κB ligand (sRANKL), osteoprotegerin (OPG), glucose (GL), total protein (TP), and albumin (AL) between women with preterm and term rupture of fetal membranes and evaluation of prognostic values of all above in diagnostic of premature labor. Ninety-eight women in singleton pregnancy presenting with premature rupture of fetal membranes were included and divided into two groups: A - 49 women after 37 weeks and B - 49 women before 36 weeks of gestation. Plasma levels of sRAGE, OPG, TP, and AL were significantly lower in group B, and RE and GL plasma levels were higher in this group. The high prognostic values for sRAGE and sRANKL in the prognosis of spontaneous delivery after preterm rupture of membranes (pPROM) were found. The authors concluded that sRAGE and sRANKL serum levels could be a useful prognostic factors after pPROM. Resistin can play role in pathogenesis of rupture of membranes in premature pregnancy.

Preterm labour
Figure 1.
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