IMR Press / CEOG / Volume 46 / Issue 2 / DOI: 10.12891/ceog4708.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Successful live delivery despite an inappropriate rise in the serial human chorionic gonadotropin level
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1 Cooper Institute for Reproductive and Hormonal Disorders, P.C., Mt. Laurel, NJ, USA
2 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA
*Correspondence: (J.H. CHECK)
Clin. Exp. Obstet. Gynecol. 2019, 46(2), 297–298;
Published: 10 April 2019

Purpose: To describe a second case of viability past the first trimester despite an inappropriate rise of the serum human chorionic gonadotropin (hCG) levels in the early pregnancy. Materials and Methods: A serum beta hCG level was obtained 17, 28, and 31 days after conception. Serial sonographic studies were performed throughout the first trimester and into the early second trimester. Results: The first serum hCG level at 17 days from conception was appropriate at 484 mIU/mL. The serum beta hCG level did not appropriately increase at 28 and 31 days (4, 844 and 9, 585 mIU/mL), respectively. Nevertheless fetal viability was seen on sonography throughout the first and early second trimesters She delivered a full-term healthy baby. Also for the first time a full-term delivery of a healthy baby from the first described case is reported (this case had only described surviving the first trimester. Conclusions: A delivery of a healthy baby despite inappropriate rising serial beta hCG levels is possible but rare.

Serial hCG levels
Live delivery
Doubling time
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