IMR Press / CEOG / Volume 46 / Issue 2 / DOI: 10.12891/ceog4599.2019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report
The course and outcome of pregnancy in patient with concomitant Gilbert syndrome and hereditary spherocytosis: a unique case report
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1 National Research Center of Mother and Child Health, University Medical Center, Astana, Kazakhstan
2 Department of Medicine, Nazarbayev University, School of Medicine, Astana, Kazakhstan
3 Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburg School of Medicine, Pittsburg, Pennsylvania, USA
*Correspondence: (M. TERZIC)
Clin. Exp. Obstet. Gynecol. 2019, 46(2), 320–322;
Published: 10 April 2019

Gilbert syndrome (GS) is an autosomal dominant mild unconjugated hyperbilirubinemia. Hereditary spherocytosis (HS) is an inherited condition of non-immune heterogeneous hemolytic anemia. These two diseases can be very rarely diagnosed in one patient, but there is not one case reported in pregnant patient. The authors present a unique case of concomitant both diseases in pregnancy. The patient was 25-years-old, conceived spontaneously, and carefully observed throughout the pregnancy. Considering that both diseases might have a detrimental influence on pregnancy course and outcome, especially in this case with severe form of HS, the woman was hospitalized and carefully observed until the end of pregnancy. She delivered vaginally without any feto-maternal complications. In conclusion, coexisting GS and HS during pregnancy deserve careful monitoring and up-to-date treatment. This case report shows that a contemporary approach to the pregnant patient with GS and HS can result in the delivery of a healthy baby without any complications.

Gilbert syndrome
Hereditary spherocytosis
Pregnancy outcome
High-risk pregnancy
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