IMR Press / CEOG / Volume 45 / Issue 6 / DOI: 10.12891/ceog4212.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Maternal and perinatal outcomes in early onset and late onset preeclampsia
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1 Istanbul University, Cerrahpasa School of Medicine, Department of Obstetric and Gynecology, Istanbul, Turkey
Clin. Exp. Obstet. Gynecol. 2018, 45(6), 837–841;
Published: 10 December 2018

Purpose: This study was performed to compare the clinical findings and identify differences in risk factors between early-onset preeclampsia (EO-PE) and late-onset preeclampsia (LO-PE). Materials and Methods: This retrospective study included 516 women with singleton pregnancies and preeclampsia (none of them had superimposed preeclampsia on chronic hypertension) who delivered in a tertiary care center. Clinical findings, and maternal and perinatal outcomes were compared between early (< 34 weeks’ gestation) and late (≥ 34 weeks’ gestation) onset of the disease. Results: Incidences of nulliparity, previous preterm births, stillbirths, and first trimester abortions were significantly higher in women with EO-PE (p < 0.05). History of disease other than chronic hypertension (especially diabetes mellitus) and previous term births were significantly higher in women with late-onset disease (p < 0.05). The mean gestational week at delivery and mean birth weight were significantly lower in early-onset disease (p < 0.05). Stillbirths, early and late neonatal deaths, and cases where the mother’s life at risk were significantly higher in women with early-onset disease (p < 0.05). Conclusions: EO-PE appears to be mediated by the placenta and associated with higher incidence of perinatal, neonatal and maternal deaths, and maternal nearmiss cases.
Maternal mortality
Perinatal mortality
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