IMR Press / CEOG / Volume 45 / Issue 6 / DOI: 10.12891/ceog4088.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Obstetric factors associated with salivary cortisol levels of healthy full-term infants immediately after birth
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1 Department of Nursing, Nagoya University Graduate School of Medicine, Higashi-ku, Nagoya, Aichi, Japan
2 Department of Medical Technology, Nagoya University School of Health Sciences, Higashi-ku, Nagoya, Aichi, Japan
3 Department of Nursing, Sugiyama Jogakuen University, Chikusa-ku, Nagoya, Aichi, Japan
4 Aichi Medical University College of Nursing, Nagakute, Aichi, Japan
Clin. Exp. Obstet. Gynecol. 2018, 45(6), 828–832;
Published: 10 December 2018

Purpose: To evaluate the contribution of demographic and obstetric factors to birth stress as measured by salivary cortisol levels in healthy full-term infants. Materials and Methods: Ninety-three newborn infants were born vaginally after uncomplicated pregnancies in Japan. An observational study was conducted in 2009. Saliva was collected at one minute after checking Apgar scores and determined using a commercial high-sensitivity enzyme immunoassay kit. Results: In multiple linear regression analysis, length of second-stage labor [β (95% confidence interval) = 0.041 (0.022–0.059), standardized β = 0.452] and bleeding immediately after birth [β (95% confidence interval) = 0.006 (0.001–0.010), standardized β = 0.239] were mutually and independently associated with infant salivary cortisol levels. Conclusion: The length of second-stage labor and third-stage bleeding may be causative factors or factors reflecting the cause of infant stress. This finding also provides support for the use of salivary cortisol levels in evaluating infant stress.
Salivary cortisol
Spontaneous birth
Length of second-stage labor
Bleeding at third-stage
Healthy full-term infant
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