IMR Press / CEOG / Volume 45 / Issue 5 / DOI: 10.12891/ceog4141.2018

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Analysis of the cytokine profile (IL-2, IL-4, IL-6, IL-10, IL-17, IFN - γ and TNF-α) on threatened miscarriage
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1 Department of Maternal and Child Health, Poznan University of Medical Sciences, Poznan, Poland
2 Department of Immunology, Chair of Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland
3 Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland
4 Clinic of Perinatology and Gynecology, Poznan University of Medical Sciences, Poznan, Poland
5 Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd Departments of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland
Clin. Exp. Obstet. Gynecol. 2018, 45(5), 661–664;
Published: 10 October 2018

Objectives: The purpose of our study was to analyze the cytokine profile in threatened miscarriage, defined as vaginal bleeding and uterine contractions with a closed cervix, occurring before the end of week 22 of gestation. Materials and methods: The study included 46 women hospitalized at the Obstetrics & Gynecology Clinical Hospital. Group 1 comprised of 14 patients diagnosed with threatened miscarriage, prior to pharmacological treatment. Group 2 comprised of 20 patients with identical diagnoses. The patients were administered drotaverine hydrochloride (3x40 mg) and progesterone transvaginally (2x100 mg). Group 3 constituted the control group, comprising of 12 women in normally-progressing pregnancy, before completing week 22 of gestation. Results: The present analysis was focused on the cytokine profile of the women included in the study, but no considerable changes in cytokine concentration were observed. The results of determining the IFN-γ and TNF-α, IL-2, IL-4, IL-6, IL- 10, IL-17, and CRP levels in all groups proved to be comparable; moreover, no considerable differences were found in the CRP level or vaginal flora. Conclusions: The present authors failed to identify any significant differences in the cytokine profile between patients in normally-progressing pregnancy and patients diagnosed with threatened miscarriage. This finding needs to be confirmed in a study in a larger group of pregnant women.
Threatened miscarriage
Prenatal care
Physiology of reproduction
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