IMR Press / CEOG / Volume 44 / Issue 3 / DOI: 10.12891/ceog3175.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Is early embryo cleavage a factor to increase success in all types of ICSI indications?
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1 Department of Obstetrics and Gynecology, Suleymaniye Training and Research Hospital, Istanbul, Turkey
2 Department of Obstetrics and Gynecology, Division Of Reproductive Endocrinology, IVF-ET Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
3 Department of Obstetrics and Gynecology, Bagcilar Training and Research Hospital, Bagcilar, Istanbul, Turkey
4 Department of Histology and Embryology, Koc University School of Medicine, Sariyer, Istanbul, Turkey
Clin. Exp. Obstet. Gynecol. 2017, 44(3), 353–358;
Published: 10 June 2017
Purpose: The authors aimed to compare early embryo cleavage with pregnancy rates in intracytoplasmic sperm injection/embryo transfer (ICSI/ET) cycles due to male infertility or tubal factor infertility (TFI). Materials and Methods: 412 ICSI/embryo transfer cycles undergoing treatment for over two years were prospectively analyzed; 337 of the cycles were due to male infertility, whereas 75 suffered from tubal factors. Non-early cleaved (NEC) embryos were used for ET in 271 male factor and 67 tubal factor cycles, whereas early cleavage embryos were used for embryo transfer in 66 male factor and eight tubal factor cycles. Results: In 66 out of 337 cycles (19.58 %) in male factor group and in eight out of 75 tubal factor cycles (10.66%), early cleavage (EC) embryos were obtained (p = 0.069). The clinical pregnancy rate was significantly elevated in EC subgroup (34.8%) compared to NEC subgroup (20.6%) (p = 0.015) in the male factor infertility group. The clinical pregnancy rate was non-significantly elevated in EC subgroup (37.5%) compared to NEC subgroup (23.8%) (p = 0.410) in the TFI group. Conclusions: The authors found that the implantation and pregnancy success of EC embryos vary with the therapeutic indication. The success rate would be low even with usage of EC embryos in untreated cycles of TFI.
Early cleavage
Tubal factor infertility
Male factor infertility
Pregnancy rate
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