IMR Press / CEOG / Volume 44 / Issue 2 / DOI: 10.12891/ceog3218.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Chromosomal microarray analysis in prenatal diagnosis
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1 Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Clin. Exp. Obstet. Gynecol. 2017, 44(2), 177–179;
Published: 10 April 2017

Genome copy number variation (CNV) is an important cause of genetic and developmental disorders. In recent years, chromosomal microarray analysis (CMA) technology to test for genomic copy number variation has been developed and gradually applied in prenatal diagnostics, offering high diagnostic ability. Here, the authors summarise the CMA established in clinical settings, as well as the significance and clinical application of the standard analyses. They also emphatically discuss the key problems in the establishment process of the platform in prenatal diagnostics in the clinic.
Genome copy number variation
Chromosomal microarray analysis
Prenatal diagnosis
Detection platform
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