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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
IL-23, IFN-α, and IFN-β in the vaginal fluid of patients suffering from vulvovaginal candidosis
T. Kolben1, *, K. Pieper2, C. Goess1, T. Degenhardt1, N. Ditsch1, T. Weissenbacher3, E.R. Weissenbacher1, T.M. Kolben1
1 Department for Obstetrics and Gynecology, University Hospital Munich - Grosshadern, Ludwig-Maximilians-University, Munich, Germany
2 Department for Ophthalmology, Hospital Darmstadt, Darmstadt, Germany
3 Department for Obstetrics and Gynecology, University Hospital Munich - Innenstadt, Ludwig-Maximilians-University, Munich, Germany
Clin. Exp. Obstet. Gynecol. 2017, 44(1), 7–10; https://doi.org/10.12891/ceog3391.2017
Published: 10 February 2017
Purpose of the investigation: Vulvovaginal candidosis (VVC) is a common vaginal infection affecting almost 75% of all women once per lifetime. Vaginal associated immunity is important in the protection against VVC. The purpose of this study was to evaluate a potential role of IL-23, IFN-α, and IFN-β in the local immune response against VVC. Materials and Methods: The study included 202 non-pregnant women; 71 patients with clinical symptoms of VVC and 131 asymptomatic patients served as control. IL-23, IFN-α, and IFN-β were measured in the vaginal fluid by ELISA. Microbiological cultures were used for Candida detection. Results: C. albicans was detected in 67.6% of patients, C. glabrata in 21.1% of patients, and 5.6% were infected with C. krusei or coinfected with C. albicans and C. krusei. Levels of IL-23 (p < 0.001) and IFN-β (p < 0.017) were significantly lower in the VVC group. IFN-α was elevated in the VVC group compared to the asymptomatic patients (p < 0.001). Conclusion: IL-23 and IFN-β seem to play a protective role against VVC. Decreased levels in VVC patients suggest a compromised local immune response at the time of occurrence of symptoms. In contrast, IFN-α seems to be released once the infection has occurred. These cytokines may be prospective targets in the treatment and prevention of primary and recurrent vaginal infections with Candida species.