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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Repeated intracyclic clomiphene citrate therapy can be more effective than hMG therapy in inducing ovulation: case report
M. Kawamura1,*, Y. Aoki2, R. Kanda1, H. Nakagomi3, Y. Tsukahara1, N. Hashimura1
1 Department of Obstetrics and Gynecology, Kohseichuo General Hospital
2 Department of Obstetrics and Gynecology, Nihon University School of Medicine
3 Nakagomi Clinic, Tokyo (Japan)
Clin. Exp. Obstet. Gynecol. 2009, 36(2), 82–84;
Published: 10 June 2009
Purpose of investigation: When clomiphene citrate is ineffective in the treatment of anovulation, hMG administration is typically selected. However, high-dose hMG therapy is associated with a variety of adverse events. We describe the use of a modified clomiphene citrate regimen that was successful in increasing the effectiveness of ovulation induction. Case report: A patient who did not initially respond to clomiphene citrate therapy required a total dose of 2400 IU hMG to prodeuce mature follicles. However, because of the physical and emotional burdens on the patient, and the possibility of multiple pregnancy and ovarian hyperstimulation syndrome, re-treatment with clomiphene citrate was then selected. Two courses of clomiphene citrate administered at a fixed interval during the same cycle safely induced ovulation. After initial induction of ovulation, her ovulatory failure improved and natural ovulation occurred. Conclusions: Repeated intracycle clomiphene cirate therapy may be more effective than hMG therapy in inducing ovulation in some patients.