IMR Press / CEOG / Volume 29 / Issue 4 / pii/2002065

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

The importance of number of blastomeres when embryos are transferred in the absence of controlled ovarian hyperstimulation

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1 The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, New Jersey (USA)
Clin. Exp. Obstet. Gynecol. 2002, 29(4), 257–258;
Published: 10 December 2002

Purpose: To determine if the previous findings that transferring embryos with a higher number of blastomeres results in higher pregnancy rates following fresh but not frozen embryo transfer (ET) was related to the use of controlled ovarian hyperstimulation (COH) in the former but not in the latter. Methods: Retrospective review of pregnancy and implantation rates following fresh embryo transfer of donor egg recipient cycles (where no COH is used) vs frozen ETs during the same time period according to whether there was at least one embryo with eight blastomeres transferred or not. Results: Significantly higher pregnancy rates with an 8-cell ET in donor oocyte recipient cycles but not frozen ETs. Conclusions: A less favorable uterine environment caused by the use of high dose gonadotropin is not responsible for the once again observed difference in higher pregnancy rates with higher blastomere number in fresh vs frozen ET. However, an effect of the gonadotropin releasing hormone analogue was not ruled out by this study.

Controlled ovarian hyperstimulation
Blastomere number
Oocyte recipient
Frozen embryo transfer
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