IMR Press / CEOG / Volume 20 / Issue 4 / pii/1993036

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

A rabbit model for the evaluation of minimal access treatment of ectopic pregnancy in humans, using intrachorionic injection and local hyperthermia

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1 Clinic Dr. Guth, Juergensallee 46, D-2000 Hamburg 52, Germany
2 Department of Obstetrics and Gynecology, Christian Albrechts University Clinic, and Michaelis School of Midwifery, D-2300 Kiel, Germany
3 Anatomical Institute, University of Hamburg, D-2000 Hamburg 20, Germany
Clin. Exp. Obstet. Gynecol. 1993, 20(4), 226–235;
Published: 10 December 1993

Rabbits at mid pregnancy were used as experimental models for investigating the feasibility of intrachorionic injection therapy in human ectopic pregnancy. Also, exposure of rabbit pregnancy to hyperthermia of 45 degrees C was studied. The experiments were followed by serial serum progesterone levels and by light as well as electron microscopy. Intrachorionic injection of different drugs led to demise in 92% of gestations. Application of hyperthermia to the pregnant rabbit uterus led in 94% to demise of gestations. Impairment of the reproductive functions after exposure did not occur. Injection was more effective up to day 15 of pregnancy, while hyperthermia had better results in older gestations. Morphological reactions to injection of different drugs and to hyperthermia were similar. Irreversible damage to the uterine wall was not observed. Intrachorionic injection of drugs may be a suitable treatment of human ectopic pregnancy. Application of hyperthermia may be a promising future therapy.

Ectopic pregnancy
Minimal access treatment
Intrachorionic injection
Local hyperther­mia
Animal studies
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