IMR Press / CEOG / Volume 15 / Issue 1-2 / pii/1634257154401-82580747

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
Relaxin deficiency in the placenta as possible cause of cervical dystocia
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1 Department of Obstetrics and Gynecology - University of Tubingen (F.R.G.)
2 Department of Physiological Chemistry - University of Tubingen (F.R.G.)
Clin. Exp. Obstet. Gynecol. 1988, 15(1-2), 38–46;
Published: 10 March 1988

In a case of cervical dystocia which had to be delivered by caesarean section, the placenta was examined for relaxin content. The placenta was processed by acidic acetone extraction and separation of the raw extract on a carboxymethylcellulose column. The activity of relaxin was estimated by means of heterologous porcine radioimmunoassay. The elution profile of the placenta extract showed significant differences to that of the placenta in normal deliveries i.e. there was no evidence of typical protein peaks with relaxin activity. It is suggested that there is possibly a causal relationship between the lack of placental relaxin and the pathological behaviour of the cervix during delivery.
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