IMR Press / CEOG / Volume 14 / Issue 3-4 / pii/1634257549994-822118462

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
A search for new anti-herpes virus compounds
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1 School of Medicine, Institute of Microbiology -University of Padua (Italy)
1 Department of Pharmaceutical Sciences -University of Camerino (Italy)
2 Department of Organic Chemistry -University of Padua (Italy)
Clin. Exp. Obstet. Gynecol. 1987, 14(3-4), 140–144;
Published: 10 September 1987

This Study reports on the synthesis and the activity of a series of new compounds of nucleoside-type structure. They are characterized for being differently substituted in the aromatic. ring of the base (deazoadenosine derivatives) or by bearing a dansyl group in the sugar moiety (dansylthymidine). One molecule belonging to this latter class of compounds (the 3'-0- dansylthymidine) is showing an anti-herpesvirus potential while being active in inhibiting the virus-encoded enzyme thymidine kinase. This finding may represent an important step for the synthesis of new enzyme inhibitors and it is discussed in terms of future developments of more active congeners.
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