- Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Division of Cardiology, University of British Columbia, Vancouver, BC, Canada; Cardiology Staff Vancouver Hospital, Vancouver, BC, CanadaInterests: fundamental basis of CVD; translational medicine; heart failure; risk factors; cardiovascular genetics; clinical electrophysiology; health care organization and managemnt; cardiovascular epidemiology; cardiovascular pharmacology
The diagnosis of heart failure and of its various types can be challenging. The main biomarkers in clinical use, BNP and NT-proBNP, have been very useful for both the diagnosis and prognosis of heart failure. However, neither of these biomarkers is 100% sensitive or specific for the diagnosis of heart failure. Furthermore, a large number of factors such as age, renal failure, obesity, atrial arrhythmias and cardiotoxic drugs can alter the serum levels of BNP and NT-proBNP. This has led to an increased interest in identifying other biomarkers that can be readily measured in the blood and that provide a greater level of sensitivity and specificity for the diagnosis of heart failure. Biomarkers that indicate a patient's prognosis more accurately should allow clinicians to better apply current therapeutics, as well as encourage the development of new agents for the management of heart failure.
The objectives of this special issue are to collect critical evaluations of new biomarkers that may assist in the diagnosis of heart failure, and to evaluate their accuracy in assessing the prognosis of different kinds of heart failure.
Prof. Simon W Rabkin
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