IMR Press / RCM / Special Issues / 1637915297974

Advances in Total Artificial Heart Science and Research

Submission deadline: 15 July 2022
Special Issue Editor
Georg M. Wieselthaler, MD
Division of Cardiothoracic Surgery, University of California San Francisco, San Francisco, CA, USA
Interests: Ventricular assist devices (VAD); Cardiac transplantation
Special Issue Information

Dear Colleagues,

For many decades scientists dreamed of replacing the failing human heart with an artificial machine. Only technical advances and application of newest technologies of the last couple decades made it possible to develop feasible pumps that can reach this task. Starting in the 1930s with Vladimir Demikhov's first complete mechanical support of a dog′s circulation for 5,5 hours with the natural heart excised, followed by extensive research and developments of the group around Willem J. Kolff in Cleveland in the 1950s and 1960s, this research cumulated in the first clinical application of a total artificial heart (TAH) in Houston in 1969, developed by Domingo Liotta and implanted by Denton A.Cooley. The field experienced another culmination in the clinical application of a Jarvik 7 TAH as chronic implant into Mr. Barney Clark in 1982 in Salt Lake City. For a long period of time the total artificial heart consisted of two separate pumps tried to mimic the pulsatility of the natural heart and was powered by pressurized air. Recently, rotary pump technology was implemented resulting in smaller, more compact, electric driven pumps.

This special issue of Reviews in Cardiovascular Medicine will be dedicated to the current status of research and the science of total artificial hearts and I invite everybody working in this exiting field to participate with their contributions in order to foster our understanding of the applied technology and newest results of their clinical application.

Prof. Georg M. Wieselthaler

Guest Editor

Total artificial heart
Mechanical circulatory support
Biventricular support
Bridge to transplantation
Destination therapy
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.

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