Vascular Injury: Basic, Translational and Clinical Insights and Therapeutic Implications

Dear Colleagues,

Observations from basic, translational and clinical research studies provide compelling evidence that vascular injury plays a key role in the development of coronary artery disease, peripheral artery disease, pulmonary vascular disease, restenosis after balloon angioplasty or stenting, and transplant-associated arteriopathy. Endothelial injury is the most proximal event in the development of vascular disease. The endothelium is a dynamic organ regulated by laminar blood flow and transcription factors that confer anti-adhesive, anti-thrombotic and anti-proliferative properties mediated, in part, by NO that also controls microcirculatory blood flow and the delivery of oxygen to tissues. This review will highlight new molecular and cellular insights into diverse forms of vascular injury—pollution, non-pulsatile flow with left ventricular assist device, SARS-CoV-2 infection, transplant rejection and drug-eluting stenting—and repair responses with a particular focus on the importance of inflammation, downstream intracellular signaling and identification of new therapeutic targets.

Prof. Daniel I. Simon and Prof. Teruo Inoue

Guest Editors

In this special issue, we recommend review articles with approximately 5,000 words and up to 100 references with 1-2 figures, 1-2 tables.

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.