- Anindita Das, PhDDepartment of Internal Medicine, Division of Cardiology, Virginia Commonwealth University, VA, USAInterests: Myocardial ischemia/reperfusion injury; Myocardial pre- and post-conditioning; mTOR signaling; Phosphodiesterase-5 inhibitor; Doxorubicin-induced cardiotoxicity; Protein kinase G; STAT3 signaling; microRNA; Inflammation; Breast cancer
MicroRNAs (miRs), a class of short single-stranded noncoding RNA, is an intricate post-transcriptional modulator of critical gene expression, either by inhibiting messenger RNA (mRNA) translation or by promoting mRNA degradation. They play a significant role in major physiological and pathological processes, such as differentiation, cell cycle, proliferation, apoptosis, autophagy and cellular metabolism. The most extensively studied miRNAs are abundantly present in many cardiac cell types including fibroblasts, endothelial cells and cardiomyocytes. Dysregulation or aberrant expression of individual or cluster of miRNAs is linked to a variety of diseases, including cardiovascular pathogenesis and its risk factors such as diabetes, hypertension, atherosclerosis, arrhythmia, myocardial infarction, cardiomyopathy and heart failure. In the last decade, considerable research has been conducted to understanding their mechanisms of actions in the pathophysiology for developing diagnostic biomarkers and therapeutics for cardiovascular disease (CVD).
However, due to the complexity of their pathogenic mechanisms, deciphering the precise roles of specific miRNAs in cardiac pathologies is challenging. Many studies have found that inhibition or restoration of specific miRNAs play significant roles in cardioprotection. Since circulating serum levels of many miRNAs have been associated with CVD, they are considered to be promising biomarkers and therapeutic targets. Therefore, future studies are warranted to developing new therapeutic as well as diagnostic approaches using miRNAs in CVD.
To advance our knowledge to developing the miRNA-based therapeutic approaches, this Special Issue will highlight the identification and characterization of new miRNAs and their novel targets in the pathogenesis of CVD. We are inviting reviews, perspectives, and original research articles from experts around the world on miRNA signaling pathways, biogenesis, extracellular function, biomarkers, miRNA immune regulation, therapeutics, including miRNA delivery systems. The robust basic and clinical breakthrough research in miRNAs may advance the effective miRNA-based therapeutics to manage CVD.
Prof. Dr. Anindita Das
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.
Pleiotropic Role of MicroRNA-17-92 Cluster in Cardiovascular Diseases and Cancer
Anindita Das et al.