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New Drug-Eluting Stent Platforms to Prevent Stent Thrombosis
1 The Heart Center of Greater Cincinnati and The Lindner Center at The Christ Hospital, Cincinnati, OH; The Ohio State University Department of Medicine and Division of Cardiology, Columbus, OH
Rev. Cardiovasc. Med. 2007, 8(S1), 34–43;
Published: 20 January 2007
Although earlier reports from randomized controlled clinical trials suggested that the incidence of stent thrombosis following drug-eluting stent (DES) implantation was similar to or less than that observed following bare-metal stent deployment, longerterm follow-up has revealed a persistent, protracted risk for thrombosis following DES. This apparent divergence in risk for thrombosis becomes evident beyond 6 to 12 months following deployment. The proposed etiologies of late DES thrombosis are multifactorial and differ somewhat from those factors incriminated in bare-metal stent thrombosis. Prevention strategies are in development to address polymer hypersensitivity/inflammatory response, delayed endothelialization/vessel healing, late incomplete stent apposition, persistence of the underlying endoluminal metal prosthesis, and discontinuation of antiplatelet therapies.