IMR Press / RCM / Volume 7 / Issue S4 / pii/1561344068803-1657091227

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Optimizing Antiplatelet Therapy for the ACS Patient: Reacting to Clinical Trial Data from the ISAR-REACT-2 Studies
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1 Gill Heart Institute, University of Kentucky, Lexington, KY
Rev. Cardiovasc. Med. 2006, 7(S4), 12–19;
Published: 20 August 2006
Antiplatelet therapy is the cornerstone of treatment for patients with an acute coronary syndrome (ACS). However, patients presenting with possible ACS are a heterogeneous population, and there is a choice of many potential combination antiplatelet therapies, with aspirin, thienopyridines (eg, clopidogrel), and glycoprotein (GP) IIb/IIIa antagonists. The ISAR-REACT-2 trial investigated the optimal application of triple (aspirin + thienopyridine + GP IIb/IIIa inhibitor) versus dual (aspirin + thienopyridine) antiplatelet therapy for patients with ACS undergoing percutaneous coronary intervention. Abciximab was associated with a significant 25% relative reduction in risk for the 30-day combined endpoint of death, myocardial infarction, or urgent target vessel revascularization. All of this benefit was confined to the patients with elevated troponin levels. The data indicate that troponin can be used as a biomarker to identify patients most likely to benefit from the addition of a GP IIb/IIIa antagonist.
Antiplatelet therapy
GP IIb/IIIa antagonists
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