IMR Press / RCM / Volume 6 / Issue S2 / pii/1561344108443-1593319623

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Device Trials in Heart Failure: A Focused Summary
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1 The New England Cardiac Arrhythmia Center, Division of Cardiology, Tufts-New England Medical Center, Boston, MA
Rev. Cardiovasc. Med. 2005, 6(S2), 21–31;
Published: 20 February 2005
Abstract
Despite considerable progress in heart failure management with pharmacologic agents, measures to bring about significant improvements in morbidity and mortality are still needed. Cardiac resynchronization therapy (CRT) is a means to enhance myocardial function by stimulating the failing left ventricle at or near the time of right ventricular activation to synchronize ventricular depolarization. Current data from randomized, controlled trials suggest that CRT benefits patients with moderate to severe heart failure and have shown that this therapy significantly reduces mortality and hospital admissions in this group. In addition to CRT, implantable cardioverter-defibrillators have been evaluated in heart failure patients with significantly reduced left ventricular function and have been shown to reduce mortality from sudden cardiac death. This article summarizes recent device trials and discusses how best to apply their results to clinical practice.
Keywords
Biventricular pacing
Cardiac resynchronization therapy
Heart failure
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