IMR Press / RCM / Volume 5 / Issue S2 / pii/1561344985976-798470080

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Optimal Stent Design for Drug Delivery
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1 Cardiovascular Division, Brigham and Women's Hospital, Boston, MA
Rev. Cardiovasc. Med. 2004, 5(S2), 9–15;
Published: 20 February 2004
The efficacy and safety of drug-eluting coronary stents might differ depending on the pharmacologic agents and stent delivery systems used. Recent research has focused on the various constituents of drug-delivery stents, including the stent backbone, materials used as drug-delivery vehicles, and the physicochemical properties of the pharmacotherapeutic agents themselves. Metal stents coated with an outer layer of polymer (bioabsorbable or non-bioabsorbable) can be drug-loaded, thus providing more controlled and sustained drug delivery and allowing more optimal drug–tissue interactions. Among the next generation of drug-eluting stents will be a stent that uses the non-bioabsorbable polymer phosphorylcholine to release the sirolimus analogue ABT-578; another stent will use a highly deliverable cobalt-chromium metal alloy stent platform and, for the first time, a bioabsorbable polymeric coating (thin-film polylactic acid) for drug encapsulation and release.
Percutaneous coronary interventions
Coronary stents
Drug-delivery systems
Stent design
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