IMR Press / RCM / Volume 4 / Issue S4 / pii/1561439365311-2046108795

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Neurohormonal Regulation and the Overlapping Pathology Between Heart Failure and Acute Coronary Syndromes
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1 Virginia Commonwealth University Health System, Veterans Health Administration, Richmond, VA
Rev. Cardiovasc. Med. 2003, 4(S4), 29–36;
Published: 20 July 2003
An understanding of the dynamic relationship between the coronary artery and left ventricular (LV) function is important in diagnosing and treating acute coronary disease. Measurement of B-type natriuretic peptide (BNP) provides rapid and accurate identification of patients with impaired LV function, which has proven valuable in differentiating between congestive heart failure (CHF) and symptoms attributable to pulmonary etiologies. Coronary artery and ventricular pathophysiology both are characterized by injury, functional aberrations, and subsequent remodeling. Ischemia occurs in both and accounts for virtually all significant adverse outcomes. The difference in BNP elevations seen in acute ischemia compared with those observed in chronic CHF is striking: Although even small BNP elevations in acute coronary syndromes have powerful prognostic value, it is not likely that they can be effectively used as a diagnostic marker for ischemia.
Acute coronary syndromes
B-type natriuretic peptide
Congestive heart failure
Left ventricular function
Myocardial infarction
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